I use Presto with PocketCasts on my Nexus S 4G running Android ICS (4.0.4). When I'm listening to a podcast and receive a call, playback is suspended. When I hang up, playback resumes properly, but the controls are unresponsive. The only way to stop playback is to force stop Presto in Settings or power cycle the phone.
EDIT: Sorry for the duplicates. I received a timeout from the server and resubmitted without realizing that the post had in fact been submitted.